Mode-pairing quantum key distribution with advantage distillation

Mode-pairing quantum key distribution (MP-QKD) is an easy-to-implement scheme that transcends the Pirandola--Laurenza--Ottaviani--Banchi bound without using quantum repeaters. In this paper, we present an improvement of the performance of MP-QKD using an advantage distillation method. The simulation results demonstrate that the proposed scheme extends the transmission distance significantly with a channel loss exceeding 7.6 dB. Moreover, the scheme tolerates a maximum quantum bit error rate of 8.9%, which is nearly twice that of the original MP-QKD. In particular, as the system misalignment error increases, the expandable distance of the proposed scheme also increases. The proposed system is expected to promote the practical implementation of MP-QKD in a wide range of applications, particularly in scenarios involving high channel losses and system errors

Experimental quantum key distribution with source flaws

Decoy-state quantum key distribution (QKD) is a standard technique in current quantum cryptographic implementations. Unfortunately, existing experiments have two important drawbacks: the state preparation is assumed to be perfect without errors and the employed security proofs do not fully consider the finite-key effects for general attacks. These two drawbacks mean that existing experiments are not guaranteed to be secure in practice. Here, we perform an experiment that for the first time shows secure QKD with imperfect state preparations over long distances and achieves rigorous finite-key security bounds for decoy-state QKD against coherent attacks in the universally composable framework. We quantify the source flaws experimentally and demonstrate a QKD implementation that is tolerant to channel loss despite the source flaws. Our implementation considers more real-world problems than most previous experiments and our theory can be applied to general QKD systems. These features constitute a step towards secure QKD with imperfect devices.Comment: 12 pages, 4 figures, updated experiment and theor

Experimental Quantum Fingerprinting

Quantum communication holds the promise of creating disruptive technologies that will play an essential role in future communication networks. For example, the study of quantum communication complexity has shown that quantum communication allows exponential reductions in the information that must be transmitted to solve distributed computational tasks. Recently, protocols that realize this advantage using optical implementations have been proposed. Here we report a proof of concept experimental demonstration of a quantum fingerprinting system that is capable of transmitting less information than the best known classical protocol. Our implementation is based on a modified version of a commercial quantum key distribution system using off-the-shelf optical components over telecom wavelengths, and is practical for messages as large as 100 Mbits, even in the presence of experimental imperfections. Our results provide a first step in the development of experimental quantum communication complexity.Comment: 11 pages, 6 Figure

Resource-efficient quantum key distribution with integrated silicon photonics

Integrated photonics provides a promising platform for quantum key distribution (QKD) system in terms of miniaturization, robustness and scalability. Tremendous QKD works based on integrated photonics have been reported. Nonetheless, most current chip-based QKD implementations require additional off-chip hardware to demodulate quantum states or perform auxiliary tasks such as time synchronization and polarization basis tracking. Here, we report a demonstration of resource-efficient chip-based BB84 QKD with a silicon-based encoder and decoder. In our scheme, the time synchronization and polarization compensation are implemented relying on the preparation and measurement of the quantum states generated by on-chip devices, thus no need additional hardware. The experimental tests show that our scheme is highly stable with a low intrinsic QBER of $0.50\pm 0.02\%$ in a 6-h continuous run. Furthermore, over a commercial fiber channel up to 150 km, the system enables realizing secure key distribution at a rate of 866 bps. Our demonstration paves the way for low-cost, wafer-scale manufactured QKD system.Comment: comments are welcome

Experimental quantum key distribution secure against malicious devices

The fabrication of quantum key distribution (QKD) systems typically involves several parties, thus providing Eve with multiple opportunities to meddle with the devices. As a consequence, conventional hardware and/or software hacking attacks pose natural threats to the security of practical QKD. Fortunately, if the number of corrupted devices is limited, the security can be restored by using redundant apparatuses. Here, we report on the demonstration of a secure QKD setup with optical devices and classical post-processing units possibly controlled by an eavesdropper. We implement a 1.25 GHz chip-based measurement-device-independent QKD system secure against malicious devices on \emph{both} the measurement and the users' sides. The secret key rate reaches 137 bps over a 24 dB channel loss. Our setup, benefiting from high clock rate, miniaturized transmitters and a cost-effective structure, provides a promising solution for widespread applications requiring uncompromising communication security.Comment: 28 pages, 5 figures, 4 table

High-speed measurement-device-independent quantum key distribution with integrated silicon photonics

Measurement-device-independent quantum key distribution (MDI-QKD) removes all detector side channels and enables secure QKD with an untrusted relay. It is suitable for building a star-type quantum access network, where the complicated and expensive measurement devices are placed in the central untrusted relay and each user requires only a low-cost transmitter, such as an integrated photonic chip. Here, we experimentally demonstrate a 1.25 GHz silicon photonic chip-based MDI-QKD system using polarization encoding. The photonic chip transmitters integrate the necessary encoding components for a standard QKD source. We implement random modulations of polarization states and decoy intensities, and demonstrate a finite-key secret rate of 31 bps over 36 dB channel loss (or 180 km standard fiber). This key rate is higher than state-of-the-art MDI-QKD experiments. The results show that silicon photonic chip-based MDI-QKD, benefiting from miniaturization, low-cost manufacture and compatibility with CMOS microelectronics, is a promising solution for future quantum secure networks.Comment: 30 pages, 12 figure

Th-MYCN Mice with Caspase-8 Deficiency Develop Advanced Neuroblastoma with Bone Marrow Metastasis

Neuroblastoma, the most common extracranial pediatric solid tumor, is responsible for 15% of all childhood cancer deaths. Patients frequently present at diagnosis with metastatic disease, particularly to the bone marrow (BM). Advances in therapy and understanding of the metastatic process have been limited due in part, to the lack of animal models harboring BM disease. The widely employed transgenic model, the Th-MYCN mouse, exhibits limited metastasis to this site. Here we establish the first genetic immunocompetent mouse model for metastatic neuroblastoma with enhanced secondary tumors in the BM. This model recapitulates two frequent alterations in metastatic neuroblasoma, over-expression of MYCN and loss of caspase-8 expression. Mouse caspase-8 gene was deleted in neural crest lineage cells by crossing a Th-Cre transgenic mouse with a caspase-8 conditional knockout mouse. This mouse was then crossed with the neuroblastoma prone Th-MYCN mouse. While over-expression of MYCN by itself rarely caused bone marrow metastasis, combining MYCN overexpression and caspase-8 deletion significantly enhanced BM metastasis (37% incidence). Microarray expression studies of the primary tumors mRNAs and microRNAs revealed extracellular matrix (ECM) structural changes, increased expression of genes involved in epithelial to mesenchymal transition, inflammation and down-regulation of miR-7a and miR-29b. These molecular changes have been shown to be associated with tumor progression and activation of the cytokine transforming growth factor beta (TGF-β) pathway in various tumor models. Cytokine TGF-β can preferentially promote single cell motility and blood borne metastasis and therefore activation of this pathway may explain the enhanced BM metastasis observed in this animal model.Fil: Teitz, Tal. St. Jude Children’s Research Hospital. Department of Tumor Cell Biology; Estados UnidosFil: Inoue, Madoka. St. Jude Children’s Research Hospital. Department of Tumor Cell Biology; Estados UnidosFil: Valentine, Marcus B.. St. Jude Children’s Research Hospital. Department of Tumor Cell Biology; Estados UnidosFil: Zhu, Kejin. St. Jude Children’s Research Hospital. Department of Tumor Cell Biology; Estados UnidosFil: Rehg, Jerold E.. St. Jude Children’s Research Hospital. Department of Pathology; Estados UnidosFil: Zhao, Wei. St. Jude Children’s Research Hospital. Department of Biostatistics; Estados UnidosFil: Finkelstein, David. St. Jude Children’s Research Hospital. Department of Computational Biology; Estados UnidosFil: Wang, Yong-Dong. St. Jude Children’s Research Hospital. Hartwell Center for Bioinformatics and Biotechnology; Estados UnidosFil: Johnson, Melissa D.. St. Jude Children’s Research Hospital. Animal Imaging Center; Estados UnidosFil: Calabrese, Christopher. St. Jude Children’s Research Hospital. Animal Imaging Center; Estados UnidosFil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; ArgentinaFil: Hakem, Razqallah. University of Toronto. Ontario Cancer Institute. Department of Medical Biophysics; CanadáFil: Weiss, William A.. University of California. Departments of Neurology, Pediatrics and Neurological Surgery; Estados UnidosFil: Lahti, Jill M.. St. Jude Children’s Research Hospital. Department of Tumor Cell Biology; Estados Unido